Enrichment Dispute Dominates 5th Round of US-Iran Nuclear Talks/ Newslooks/ WASHINGTON/ J. Mansour/ Morning Edition/ Iran and the U.S. held a fifth round of nuclear talks in Rome, with uranium enrichment emerging as the major hurdle. Iran demands the right to continue enriching uranium, while the Trump administration insists on a full halt in exchange for sanctions relief.

Iran-US Nuclear Talks in Rome: Enrichment the Dealbreaker – Quick Looks
- Location: Rome, Italy, at the Omani Embassy
- Parties involved: Iran, the United States, mediated by Oman
- Key US demand: Iran must cease all uranium enrichment
- Iran’s position: No deal without enrichment rights
- Why it matters: Enrichment determines how close Iran is to building a nuclear weapon
- US threat: President Trump warns of airstrikes if talks fail
- Israeli threat: Israel could unilaterally strike Iranian nuclear facilities
- Economic backdrop: Iran’s economy is reeling; its currency, the rial, recently collapsed past 1 million per USD
- Possible solution: A Middle East-based enrichment consortium floated, but Iran insists enrichment must happen domestically
- Next steps: No deal reached yet; sides remain divided
Deep Look: US-Iran Nuclear Talks in Rome Stall Over Uranium Enrichment Dispute
The fifth round of nuclear negotiations between Iran and the United States opened Friday in Rome, with uranium enrichment emerging once again as the critical sticking point in a long-running diplomatic standoff that could shape global security for years to come.
Held behind closed doors at the Omani Embassy in Rome’s Camilluccia neighborhood, the talks mark the latest attempt to curb Iran’s nuclear ambitions in exchange for lifting crippling U.S.-led economic sanctions. But as in previous rounds, Tehran’s insistence on continuing uranium enrichment — and Washington’s demand for a full halt — appears to be a fundamental dealbreaker.
Iran: “No Enrichment, No Deal”
Iranian Foreign Minister Abbas Araghchi made Tehran’s position crystal clear just hours before talks resumed, stating via the platform X: “We do NOT have a deal” without enrichment. The comment came in response to U.S. insistence that Iran stop all enrichment, even to low levels, as a condition for any sanctions relief.
“Figuring out the path to a deal is not rocket science,” Araghchi added. “Time to decide.”
Iran currently enriches uranium to near weapons-grade levels and maintains large stockpiles. U.S. intelligence believes Iran is not actively producing nuclear weapons but could do so in less than a week if it chose to. The Pentagon’s Defense Intelligence Agency recently warned that Iran’s actions have significantly shortened the “breakout time” needed to assemble a nuclear bomb.
US: No Room for Compromise
The American delegation, led by Mideast envoy Steve Witkoff and State Department policy director Michael Anton, has hardened its stance since earlier rounds. Initially open to limited enrichment at around 3.67%, the U.S. now demands a complete halt. State Department spokesperson Tammy Bruce confirmed Thursday that halting enrichment is “non-negotiable” in the current framework.
“The Iranians are at that table, so they also understand what our position is,” Bruce said.
The talks are being mediated by Oman’s Foreign Minister Badr al-Busaidi, with the Gulf sultanate once again serving as a crucial diplomatic bridge between Washington and Tehran.
Regional Risks and Israeli Threats
While diplomacy dominates the headlines, the risk of military escalation looms. President Donald Trump has repeatedly threatened airstrikes if Iran pushes too far, and Israel has openly discussed potential unilateral action to take out Iranian nuclear facilities.
On Thursday, Araghchi warned that Iran would take “special measures” to defend its facilities, and said the Islamic Republic would hold the U.S. accountable for any Israeli military action. Iranian state media also highlighted a human chain formed by students around the fortified Fordo enrichment plant, a symbolic gesture underscoring Iran’s resolve.
Alternative Proposals on the Table
One idea floated during previous rounds is the creation of a multinational enrichment consortium — possibly backed by the U.S. and regional allies — to supply Iran with low-enriched uranium for civilian use. However, Iran’s government has so far rejected this, insisting enrichment must take place within its own borders.
A similar fuel-swap plan failed in 2010, and prospects for reviving it remain slim.
Mounting Pressure on Tehran
Despite defiant rhetoric, Tehran is under enormous internal pressure to reach a deal. Inflation, international isolation, and the rial’s dramatic fall past 1 million to the dollar earlier this year have sparked unrest and fears of renewed street protests.
The Iranian regime also faces political strain over domestic issues such as hijab enforcement and growing economic inequality. With its regional network — the so-called “Axis of Resistance” — weakened by recent Israeli strikes and the fall of Bashar Assad’s government in Syria, Iran’s leverage is increasingly limited.
Sanctions Tighten as Talks Stall
While negotiations continue, the Trump administration hasn’t slowed its pressure campaign. The U.S. imposed new sanctions this week targeting Iranian imports of sodium perchlorate, a compound with potential nuclear applications. Reports suggest Iran recently received a shipment at its Shahid Rajaei port, where a deadly explosion in April further complicated the diplomatic landscape.
What’s Next?
With both sides entrenched, the path forward remains uncertain. The Trump administration is unlikely to budge on enrichment, while Iran refuses to back down on what it views as a sovereign right. Still, with Iran’s economy on the brink and regional tensions running high, both Tehran and Washington may yet find incentive to bridge the gap.
For now, however, enrichment remains the red line — and the barrier to a breakthrough.
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